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Type 2 diabetes mellitus (T2DM) and subclinical hypothyroidism are worldwide epidemic disorders. Hypothyroidism affects glucose metabolism and T2DM progresses faster in hypothyroid patients. This study aimed to assess the impact of subclinical hypothyroidism on glucose metabolism in T2DM patients. In this cross-sectional study, 52 T2DM patients and 40 controls were recruited. Fasting glucose, glycated hemoglobin, insulin, lipid profile, thyroid stimulating hormone, free triiodothyronine, free thyroxine, homeostatic model assessment of insulin resistance and β-cell function were measured. The subclinical hypothyroid group had higher blood glucose levels than the control group (p =.001). Moreover, a negative correlation was observed between glucose and free thyroxine and the homeostatic model assessment of insulin resistance in hypothyroid patients (p =.001). Homeostatic model assessment of β-cell function had a positive correlation with free thyroxine in hypothyroid patients (p =.04). 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